The role of polyprenol-linked sugars in eukaryotic macromolecular synthesis.

Polyprenol-linked sugars and glycoprotein synthesis in plants.

Introduction Protein glycosylation is a universal feature of all eukaryotic organisms and has been the subject of intensive studies for several years. Lipid-linked saccharides, or lipid-intermediates, of a type similar to those involved in the biosynthesis of cell wall polysaccharides in bacteria (see, for example, Hemming, 1974) have also been shown to participate in the formation of glycoprot...

SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

N-linked glycosylation is the most frequent modification of secreted and membrane-bound proteins in eukaryotic cells, disruption of which is the basis of the congenital disorders of glycosylation (CDGs). We describe a new type of CDG caused by mutations in the steroid 5alpha-reductase type 3 (SRD5A3) gene. Patients have mental retardation and ophthalmologic and cerebellar defects. We found that...

Macromolecular synthesis in cells infected with Herpes simplex virus

Developmental Changes of the Notochord and its Inductive Effects on the Adjacent Embryonic Germ Layers with Regard to the Role of Glycoconjugates

Notochord is an axial structure derived of embryonic mesoderm and in addition to structural supporting role in inducing nearby germinal layers, it has a basic role in formation of organs such as vertebral column, axial vessels, neural tube and primitive gut. This organ undergoes essential changes during the development process. First, arises from the primitive node and terms notochordal process...

Well-defined PE-b-PTFE diblock copolymers via combination of coordination chain transfer polymerization and condensation reaction: Facile preparation and surface modification of polyethylene film

In this paper, a series of well-defined polyethylene-b-polytetrafluoroethylene diblock copolymers (PE–b– PTFEs) were prepared by a coupling reaction of hydroxyl-terminated polyethylene (PE–OH) and isocyanateterminated 1H,1H-perfluoro-1-tetradecanol (PFDO–NCO). PE–OH was prepared by the coordination chain transfer polymerization using 2,6-bis[1-(2,6-diisopropylphenyl)imino ethyl] pyridine iron (...